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Topo-Net Spatial Entity Relationship Model for Geographic Information System Applications
Barkha Bahl,Vandana Sharma,Navin Rajpal
International Journal of Database Management Systems , 2011,
Abstract: Rapid development of Geographic Information System (GIS) has given rise to great amount of spatial database, around which a large number of GIS applications are being created. A GIS based network application for planning and management being developed in the country has typical requirement for representation of datasets at primary level .This paper examines the representation of such datasets through ER and EER models and summarizes their limitation. In order to represent the evolving databasedesign for GIS based network application Topo-Net Spatial ER was evolved and proposed with focus on representation of spatial, topological ,network and generalization aspects and has led to successful conceptual database design. The representation have been achieved through moderating EER Model with topological and network concepts and hence termed as Topo-Net Spatial ER model. The approach and representations of the same are described in the present paper. The approach and representations of the same are described in the present paper and is being demonstrated through a case study for Optical Fiber Cable Network.
Triangular Pyramid Framework For Enhanced Object Relational Dynamic Data Model for GIS
Barkha Bahl,Navin Rajpal,Vandana Sharma
International Journal of Computer Science Issues , 2011,
Abstract: GIS (Geographic Information System) data modeling is a methodology for designing spatial databases. Efficient database design is crucial to efficient GIS implementation. A model is a simplification of the complexity of reality, which makes the reality more understandable and operational. The Objective of this paper is to present an overview of various data models and to evolve an approach to design a model which can overcome the identified gaps of various models being studied for a GIS application. The proposed data model i.e. Enhanced Object Relational Dynamic Data Model enhances Object Relational Data Model (EORDM) by introducing reusability and dynamicity for the database . Reusability concept allows storage of distinct objects having same spatial representation onto a single storage space and dynamicity allows creation of relations on user's requirement. The conceptual data model for the same has been designed named Triangular Pyramid Framework which has been explained in section IV of this paper.
Boosting Geographic Information System’s Performance Using In-Memory Data Grid
Barkha Bahl,Vandana Sharma,Navin Rajpal
BVICAM's International Journal of Information Technology , 2012,
Abstract: A typical Geographic Information System(GIS) is informationsystem that integrates, stores, edits, analyzes, shares anddisplays geographic information for effective decision making.The focus here is to refine the storing and retrievingcapabilities of any GIS. GIS application have a very highperformance and scalability requirement, such as queryresponse time of less than 3 seconds, 120000 customer sessionsper hour and 100000 data addition/updates per day. Also anideal GIS application always deal with high concurrent load,frequent database access for mostly read only data, and nonlineargrowth of mostly read only data over period of time.These all are the factors which lead to performance impact inthe application. This research proceeds to understand how theIn-Memory Data-Grid solution is better than other solutionsand how can it be leveraged to implement a very highperforming and highly scalable GIS applications.
Bacterial Surface Layer Proteins: A Promising Nano-Technological Tool for Bio-Sensing Applications  [PDF]
Anjali Sharma, Barkha Singhal
Advances in Bioscience and Biotechnology (ABB) , 2019, DOI: 10.4236/abb.2019.103004
Abstract: The phenomenal rise in the demand of biosensors accelerated their rapid development and immersive applications in the myriads of fields. The essential requirement of developing efficient bio-sensing platform is to find stable well organized interfacial architecture that can serve as an excellent matrix for binding and recognizing biomolecules. In this context, the enormous potential has been envisaged in surface layer proteins that represented themselves as most primitive and simplest self-assembled system with repetitive physicochemical properties for the molecular functionalization of surfaces and various interfaces. The prominence of S-layer proteins has been broadened by integrating genetic engineering approaches for the fine tuning of functional groups and protein domains in geometrically well-defined manner. The efficient and stable binding of various nanomaterials with S-layers in regular arrays has led to paradigmatic shift in their nano-biotechnological sensing applications. More recently, functional S-layer supported lipid membranes have been generated through covalent binding of lipid molecules either with native or recombinant S-layer proteins at nano-scale dimensions serving as “proof of concept” for the development of bio-sensing platform. Thus, in the light of benefits conferred by surface layer proteins for the development of highly efficient biosensors, an exciting path has been opened for broadening their translational applications in drug delivery, disease diagnosis, vaccines development, lab-on-chip devices etc. Therefore, this review intends to describe about the importance of surface layer proteins in the development of biosensors.
Book Review: Sudha Sharma, The Status of Muslim Women in Medieval India
Barkha Dubey
- , 2018, DOI: 10.1177/0049085718781608
Abstract: Sudha Sharma, The Status of Muslim Women in Medieval India. New Delhi: SAGE Publications, 2016, 284 pp., ？750, ISBN: 9789351505662 (Hardcover)
Role of Probiotics in Pancreatic Cancer Prevention: The Prospects and Challenges  [PDF]
Barkha Singhal, Ankita Mukherjee, Shubham Srivastav
Advances in Bioscience and Biotechnology (ABB) , 2016, DOI: 10.4236/abb.2016.711045
Abstract: Pancreatic cancer is expressed as a disorder of chaos that leads to impairment in biochemical and metabolic physiology of pancreas. It is considered as the most intractable and fatal among all gastrointestinal (GI) cancers. The early occurrence of metastatic spread and the development of intrinsic and acquired resistance during drug treatment limit its prognosis at the right time. The universalized treatment involves surgical resection in which only a minority (<20%) of patients qualify due to advanced stage of disease at the time of diagnosis. Despite the rigorous technological developments in understanding the molecular mechanism of pancreatic cancer, no significant advances in efficacy of chemotherapeutic treatment have been arisen till date and still present challenges to overcome. That leads to the scientists to undergo exhaustive research to find an alternative treatment and increasing focus have been given on the studies of symbiotic relationships between microbiota and host which confers benefits to the host in many key aspects of life and form a synergistic harmony so called “super-organism”. The perturbations in the regulatory circuits of the host that control homeostasis, or alterations of the microbiome, through environmental changes (infection, diet or lifestyle), may disturb this symbiotic relationship and favors carcinogenesis in the pancreas. Research studies speculating convincing evidence that, among the gut microbiota, probiotics have demonstrated their potential role in the prevention of all stages of cancer development, but the critical question has been arisen that Can probiotics be used as preventive targets for pancreatic cancer? Thus, the efforts have been directed towards to summarize the prospective and challenging role of probiotics as preventive approach for pancreatic cancer. Though prospects of probiotics in prevention of pancreatic cancer are being great challenge among research community therefore, more rigorous and well-designed in vitro, animal and clinical studies are required for worthy manifestations.
Metabiotics: The Functional Metabolic Signatures of Probiotics: Current State-of-Art and Future Research Priorities—Metabiotics: Probiotics Effector Molecules  [PDF]
Aarti Singh, Vishakha Vishwakarma, Barkha Singhal
Advances in Bioscience and Biotechnology (ABB) , 2018, DOI: 10.4236/abb.2018.94012
Abstract: The intricate “orchestered molecular conversation” between the host and gut microbiome is one of the most dynamic research areas in recent years. The rhythmic chemical cross talk in the form of bioactive metabolites and signalling molecules synthesized by gut microbiome plays a significant role for the modulation of human health in diversified ways. They are recognized as low molecular weight (LMW) molecules having versatile chemical attributes. They possess magnificent capability of interacting with surrounding environment and controlling the genes for various genetic, biochemical and physiological functions for maintaining the homeostasis that is now-a-days termed as “small molecules microbes originated (SMOM) homeostasis” in the host. These metabolic signatures have close structural and functional resemblance with small molecules synthesized by host eukaryotic cells and dietary components. Therefore, they may be considered as universalized metabolites contributing to the remarkable phenomenon of epigenetic regulation, cell to cell communication and stability of genome manifesting the overall growth and development of the host and known as “metabiotics”. The wide panorama of utilization of probiotics is continuously expanding and conferring the major health benefits through metabiotic components are gaining tremendous momentum therefore recognized as “hidden soldiers” of the body. Therefore firstly, we outline the need and types of metabiotic molecules and depicting their role in human health. Then, we summarize their preventive and therapeutic avenues in various diseases and finally, we propose the current technological interventions, bottlenecks and future perspectives in this field that are implied for accelerating their comprehensive understanding and utilization at industrial scale.
Bacterial Surface Layer Proteins: From Moonlighting to Biomimetics: A New Horizonto Lead  [PDF]
Nimisha Gaur, Ankit Sharma, Barkha Singhal
Advances in Bioscience and Biotechnology (ABB) , 2018, DOI: 10.4236/abb.2018.98023
Abstract: The landmark discovery of moonlighting proteins embarks the significant progress in understanding the biological complexity and their closed-circuit analysis. The growing continuum in the variety of moonlighting functions paved the way for further elucidation of structural-functional aspects of protein evolution and design of proteins with novel functions. Currently, the moonlighting functions in various adhesive properties of surface layer proteins, an essential component of cell surface architecture of archaea and all phylogenetic groups of eubacteria become more prominently recognized. The remarkable credentials of surface layer proteins to self-assemble into supramolecular structures at nano-scale dimension have been exploited for the production of smart biomaterials in the form of biomimetics has been thrust area of research. The finely tuned topological features in terms of shape, size, geometry and surface chemistry of surface layer proteins are crucial for the production of biomimetics. The current developments of biomimetic lipid bilayers and composite membranes find applicability in understanding the functional dynamism of evolutionary relationship of bacterial cell envelopes and vaccine development, drug development and drug delivery. Though the development of biomimetics embraces fascination but faces with technological challenges. The plethora of literature has been available for the moonlighting aspects and nano-technological applications separately but none of the review describes towards the rhythmic transition from moonlighting functions of surface layer proteins of bacteria to biomimetics development and applications. Therefore, this review describes certain basic aspects of moonlighting functions and their mechanism of action, surface layer proteins and their moonlighting functions of commensal bacteria and their transition towards biomimetics. The recent developments of biomimetics based on surface layer proteins have been summarized and also posited different challenges and future prospects.
Role of lifestyle in the development of chronic obstructive pulmonary disease : A review
Kant Surya,Gupta Barkha
Lung India , 2008,
Abstract:
Perianal nodule due to Enterobius vermicularis: Cytomorphological spectrum on fine needle aspiration cytology with a review of literature
Barkha Gupta,Shyama Jain
- , 2018, DOI: 10.4103/tp.TP_33_17
Abstract:
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